Detection HLA-B27

We remind you that independent interpretation of the results is unacceptable, the information provided below is for reference purposes only.

HLA-B27 is a blood laboratory test used to detect a specific antigen of the HLA class I system. This marker is involved in immune system function and in the recognition of self and foreign cells in the body. The test is used to assess genetic predisposition to various autoimmune diseases, mainly of rheumatologic origin.

Indications

• ankylosing spondylitis (Bechterew’s disease)
• reactive arthritis
• psoriatic arthritis
• inflammatory diseases of the spine and joints
• acute or recurrent uveitis
• chronic inflammatory back pain, especially in young patients
• morning stiffness and reduced spinal mobility
• recurrent unexplained joint inflammation
• family history of autoimmune diseases

Procedure

• Venous blood sample collection in a laboratory setting
• Detection using molecular diagnostic methods (usually PCR) or flow cytometry, depending on the laboratory
• Quick procedure, lasting only a few minutes
• No hospitalization required
• Results are typically available within 1–3 working days

Interpretation of Results

• Positive result (HLA-B27 +): presence of the genetic marker associated with an increased risk of autoimmune diseases
• Negative result (HLA-B27 −): marker not detected, which lowers the probability of associated diseases but does not fully exclude them

Clinical Significance

• HLA-B27 is a genetic risk factor, not a disease
• It can be found in healthy individuals without symptoms
• It is more frequently associated with ankylosing spondylitis and other spondyloarthropathies
• It serves as an auxiliary diagnostic marker
• Diagnosis is established only through a combination of clinical findings, laboratory tests, and imaging studies (MRI, X-ray)

Sources:

https://www.ncbi.nlm.nih.gov/books/NBK551523/
https://www.healthline.com/health/hla-b27-antigen
https://www.verywellhealth.com/hla-b27-test-for-ankylosing-spondylitis-6748813
https://en.wikipedia.org/wiki/HLA-B27
https://emedicine.medscape.com/article/1201027-overview

IMPORTANT!

It is crucial to remember that the information provided in this section is not intended for self-diagnosis or self-treatment. If you experience any pain or exacerbation of a condition, it is essential to consult a healthcare professional for proper diagnosis and treatment. Only a qualified specialist can make an accurate diagnosis and determine appropriate treatment. To ensure the most accurate and consistent evaluation of test results, it is recommended to have them performed at the same laboratory. Different laboratories may use varying methods and units of measurement for similar tests.