Antiphospholipid antibodies, Ig M/Ig G

The antiphospholipid antibody test detects the body’s autoimmune response against phospholipids, molecules that are part of cell membranes and platelets. Antiphospholipid antibodies can increase the risk of blood clots (thrombosis) in arteries and veins, which can lead to stroke or heart attack. They are also associated with thrombocytopenia, miscarriage, premature birth, and preeclampsia during pregnancy.

The presence of these antibodies is part of antiphospholipid syndrome (APS, Hughes–Stovin syndrome), which may include thrombosis, obstetric complications, and thrombocytopenia. APS can be primary or secondary to other autoimmune diseases, such as systemic lupus erythematosus.

Role 

• Detect the presence of specific antiphospholipid antibodies.
• Assess the risk of thrombosis and obstetric complications.
• Provide diagnostic support for suspected antiphospholipid syndrome (APS).

Indications

• History of unexplained thrombosis.
• Recurrent miscarriages, especially in the second or third trimester of pregnancy.
• Preeclampsia or other pregnancy complications.
• Suspected autoimmune diseases (e.g., systemic lupus erythematosus).

Procedure

• Blood is drawn using standard venipuncture.
• The sample is analyzed in the laboratory for levels of antiphospholipid antibodies (anticardiolipin antibodies, anti-β2-glycoprotein I antibodies, etc.).

Recommendations

• Relax during blood collection.
• Inform your doctor about any medications that may affect blood clotting or immune response.
• Test results should be interpreted only by a specialist, considering the patient’s clinical context.