Helicobacter pylori, antigen (qualitative)
1 day 
Available with home visit We remind you that independent interpretation of the results is unacceptable, the information provided below is for reference purposes only.
Qualitative detection of Helicobacter pylori antigen in stool is a non-invasive test used to identify active Helicobacter pylori infection.
Helicobacter pylori is a bacterium that colonizes the gastric mucosa and may be associated with the development of chronic gastritis, gastric and duodenal ulcers, as well as other gastroduodenal disorders.
The test detects specific bacterial antigens in stool and provides a qualitative result — positive or negative. It can be used both to diagnose active infection and, under appropriate conditions, to confirm eradication of the bacterium after treatment.
Indications
- suspected Helicobacter pylori infection;
- persistent pain or discomfort in the epigastric region;
- recurrent dyspeptic symptoms;
- nausea, a feeling of gastric fullness, or bloating;
- gastritis;
- gastric or duodenal ulcer;
- evaluation of patients with gastroduodenal disorders associated with H. pylori;
- confirmation of Helicobacter pylori eradication after completion of treatment, at the interval recommended by the physician.
Procedure
For the test, a stool sample is collected in a special clean, dry container.
In the laboratory, the sample is tested for specific Helicobacter pylori antigens. The result is reported qualitatively as positive or negative.
The test is non-invasive and does not require endoscopy or gastric biopsy.
Limitations
A positive result indicates the presence of Helicobacter pylori antigens and is consistent with active infection.
A negative result does not completely exclude infection, particularly if the sample was collected during or shortly after the use of medications that may reduce the bacterial load and affect the test result.
Antibiotics, bismuth-containing medications, and proton pump inhibitors (PPIs) may cause false-negative results if the recommended interval before testing is not observed.
The result should be interpreted in the context of clinical symptoms and other investigations, as recommended by the physician.
Sources:
https://www.mayoclinic.org/diseases-conditions/h-pylori/doctors-departments/ddc-20356178
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024767/
https://my.clevelandclinic.org/health/diseases/21463-h-pylori-infection
https://www.mayoclinic.org/diseases-conditions/h-pylori/symptoms-causes/syc-20356171
https://medlineplus.gov/lab-tests/helicobacter-pylori-h-pylori-tests/
https://www.mayoclinic.org/diseases-conditions/h-pylori/diagnosis-treatment/drc-20356177
https://my.clevelandclinic.org/health/diagnostics/5217-h-pylori-tests
https://www.uptodate.com/contents/indications-and-diagnostic-tests-for-helicobacter-pylori-infection-in-adults
https://www.webmd.com/digestive-disorders/h-pylori-helicobacter-pylori
IMPORTANT!
It is crucial to remember that the information provided in this section is not intended for self-diagnosis or self-treatment. If you experience any pain or exacerbation of symptoms, it is essential to consult a doctor for proper diagnostic tests and treatment recommendations. Only a qualified healthcare professional can make an accurate diagnosis and determine the appropriate course of treatment. To ensure the most accurate and consistent interpretation of test results, it is recommended to have them performed at the same laboratory. Different laboratories may use varying methods and units of measurement for similar tests.
Preparation:
- the sample should be collected after spontaneous bowel movement in a special stool collection container;
- contamination of the sample with urine, toilet water, or other impurities should be avoided;
- sample collection after the use of laxatives, rectal suppositories, or enemas is not recommended;
- to reduce the risk of a false-negative result, testing is recommended at least 4 weeks after completing treatment with antibiotics or bismuth-containing medications;
- proton pump inhibitors (PPIs) should generally be discontinued approximately 2 weeks before testing, if permitted by the physician;
- prescribed medications should not be discontinued without medical advice; any changes to treatment should be made only upon the physician’s recommendation;
- when testing to confirm Helicobacter pylori eradication, the recommended interval after completion of treatment should be observed;
- the sample should be stored and transported according to the laboratory’s instructions.
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