Gastrointestinal IgG antibody profile: gliadin, tTG, ASCA, gastric parietal cells (PCA), intrinsic factor
2 days 
Available with home visit We remind you that independent interpretation of the results is unacceptable, the information provided below is for reference purposes only.
Gastrointestinal IgG Antibody Profile — an extended serological test for the comprehensive assessment of immunological markers associated with celiac disease, inflammatory bowel diseases, and autoimmune gastritis.
The profile includes several types of antibodies that can be used as additional markers in the diagnostic evaluation of patients with gastrointestinal symptoms, vitamin B12 deficiency, anemia, suspected celiac disease, Crohn’s disease, or autoimmune gastritis.
The test helps expand the diagnostic evaluation; however, it is not used as a standalone method to confirm or exclude a disease. The final interpretation of the results is performed by the physician, taking into account the clinical picture and the results of other investigations.
Indications
The test may be recommended in the following situations:
- persistent or recurrent diarrhea, abdominal pain, or bloating;
- unexplained weight loss;
- suspected celiac disease, particularly in cases of known or suspected IgA deficiency;
- inconclusive or conflicting results of previous tests for celiac disease;
- clinical suspicion of inflammatory bowel disease;
- need for additional diagnostic evaluation to differentiate Crohn’s disease from ulcerative colitis;
- unexplained vitamin B12 deficiency;
- macrocytic or megaloblastic anemia;
- neurological symptoms that may be associated with vitamin B12 deficiency;
- persistent or recurrent iron deficiency without an obvious cause;
- suspected autoimmune or atrophic gastritis;
- presence of other autoimmune diseases associated with gastrointestinal symptoms or deficiency states;
- need for an extended diagnostic evaluation as recommended by a gastroenterologist, hematologist, internist, or other specialist.
Profile Components
The profile includes:
- IgG antibodies to gliadin / anti-DGP IgG — a serological marker used in the evaluation of celiac disease, particularly in certain situations, including IgA deficiency.
- IgG antibodies to tissue transglutaminase / anti-tTG IgG — a marker used in the diagnosis of celiac disease, particularly in patients with IgA deficiency.
- ASCA IgG — antibodies to Saccharomyces cerevisiae — an additional marker more commonly associated with Crohn’s disease. A positive result alone does not confirm the diagnosis.
- PCA — antibodies to gastric parietal cells — may support suspicion of autoimmune gastritis and may be associated with vitamin B12 deficiency.
- Intrinsic factor antibodies — a highly specific marker for autoimmune gastritis and pernicious anemia associated with vitamin B12 deficiency.
Test Method
Serological immunological method.
The test is performed by determining specific IgG antibodies in a venous blood sample.
Procedure
A venous blood sample is collected for the test, usually from a vein in the antecubital area.
The procedure takes a few minutes and, in general, does not require any special monitoring after blood collection.
Sources:
https://pubmed.ncbi.nlm.nih.gov/23293933/
https://en.wikipedia.org/wiki/Parietal_cell
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327232/
https://en.wikipedia.org/wiki/Gliadin#:~:text=Gliadin%20(a%20type%20of%20prolamin,to%20rise%20properly%20during%20baking.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899726/
IMPORTANT!
It is very important to remember that the information in this section is not intended for self-diagnosis or self-treatment. If you experience pain or a flare-up of a condition, you should seek medical attention and a qualified healthcare provider for diagnostic tests and proper treatment. Only a qualified specialist can make an accurate diagnosis and determine appropriate treatment. For the most accurate and consistent evaluation of test results, it is recommended to have them performed at the same laboratory, as different laboratories may use different methods and units of measurement for similar tests.
Preparation:
Special fasting preparation is generally not required.
Before the test, it is recommended to:
- maintain your usual fluid intake;
- do not discontinue any medications without your doctor’s advice;
- inform your doctor and the laboratory staff about any medications you are taking and any existing medical conditions.
Important when being evaluated for celiac disease: do not start a gluten-free diet before completing the diagnostic evaluation unless otherwise recommended by your doctor. Serological testing for celiac disease should be performed while consuming gluten, as limiting or excluding gluten may reduce the levels of specific antibodies and lead to false-negative results.
If you are already following a gluten-free diet, inform your doctor before the results are interpreted.
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