Regenerative Therapy with PRGF–Endoret in Orthopedics (4 tubes)
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PRGF–Endoret® (Plasma Rich in Growth Factors) is a patented biomedical technology that enables the isolation and concentration of growth factors and regenerative proteins from the patient's own blood.
The resulting concentrate is injected into the affected area and helps reduce inflammation, relieve pain, improve microcirculation, and accelerate tissue regeneration processes. The method is widely used in orthopedics, sports medicine, rheumatology, and functional rehabilitation programs.
Indications
- Knee osteoarthritis
- Hip osteoarthritis
- Plantar fasciitis (heel spur)
- Patellar tendinitis (“jumper’s knee”)
- Chronic Achilles tendinopathy
- Lateral epicondylitis (“tennis elbow”)
- Chronic inflammatory and degenerative disorders of tendons, ligaments, and joints
- Recovery after sports injuries and musculoskeletal overuse
Procedure / Duration
The procedure begins with the collection of the patient's venous blood (approximately 36 ml) into special sterile tubes. The blood is then centrifuged, and the plasma fraction enriched with growth factors (PRGF) is separated. The resulting preparation is activated and injected into the affected joint, tendon, or soft tissues.
When necessary, the injection may be performed under ultrasound guidance to ensure maximum accuracy.
The duration of a single session is approximately 30–60 minutes.
A standard treatment course usually includes 2–3 procedures performed at one-week intervals. Subsequently, maintenance procedures may be carried out every 6–12 months, depending on the clinical indication.
Contraindications
- Active oncological diseases
- Acute local or systemic infections
- Autoimmune diseases during acute flare-ups
- Severe anemia
- Thrombocytopenia
- Sepsis and systemic inflammatory conditions
- Viral hepatitis B or C
- HIV infection
- Pregnancy and breastfeeding
- Severe psychoneurological disorders
Recovery / Restrictions
After the procedure, it is recommended to limit intense physical activity involving the treated area for several days. During the first 24 hours, patients should avoid overheating, saunas, steam baths, and hot baths.
Mild discomfort, a feeling of pressure, or moderate soreness at the injection site may persist for several days and usually resolves on its own.
To achieve optimal results, the therapy may be combined with physiotherapy, kinesitherapy, and therapeutic exercise programs.
Advantages
- Uses only the patient's own biological material
- Minimal risk of allergic reactions and immune rejection
- Absence of leukocytes reduces the likelihood of inflammatory reactions
- Standardized preparation and activation technology
- Stimulates natural tissue regeneration processes
- Helps reduce pain and inflammation
- Compatible with other treatment and rehabilitation methods
- Minimally invasive procedure with a high safety profile
Sources:
https://bti-biotechnologyinstitute.com/en/solutions/regenerative-medicine/traumatology
https://pmc.ncbi.nlm.nih.gov/articles/PMC2795806/
https://pubmed.ncbi.nlm.nih.gov/20714903/
https://www.sciencedirect.com/science/article/abs/pii/S0749806313008190
https://www.sciencedirect.com/science/article/abs/pii/S0749806312005129
https://josr-online.biomedcentral.com/articles/10.1186/s13018-020-01919-9
https://www.sciencedirect.com/science/article/pii/S2773157X23001200
Preparation:
- It is recommended to avoid intense physical activity for 24 hours before the procedure.
- Refrain from consuming alcohol on the day before the procedure.
- Maintain adequate hydration and drink sufficient water on the day of the procedure.
- A heavy meal immediately before the procedure is not recommended; a light meal 2–3 hours before the appointment is allowed.
- Inform your doctor about all medications you are taking, including those that may affect blood clotting.
- Do not discontinue any prescribed medications without prior consultation with your treating physician.
