Sex hormone-binding globulin, SHBG

Sex Hormone-Binding Globulin (SHBG) is a protein primarily synthesized in the liver that plays a key role in the transport and regulation of circulating sex hormones, mainly testosterone and estradiol.

SHBG binds these hormones in the bloodstream, regulating their biologically active (free) fraction and controlling their availability to target tissues. Through this mechanism, SHBG helps maintain hormonal balance and supports reproductive, metabolic, and endocrine processes.

SHBG levels may vary depending on age, sex, hormonal status, liver function, body weight, and the presence of metabolic or endocrine disorders.

Indications

SHBG testing is recommended in the following cases:

• Reproductive disorders (infertility, polycystic ovary syndrome, hypogonadism)
• Evaluation of hormonal imbalance in men and women
• Hirsutism, acne, or signs of androgen excess or deficiency
• Suspected endocrine disorders (diabetes mellitus, obesity, metabolic syndrome)
• Thyroid disorders (hyperthyroidism or hypothyroidism)
• Assessment of cardiovascular and metabolic risk
• Monitoring of hormone therapy or treatments affecting steroid balance

Procedure

The SHBG test is performed using a venous blood sample, usually drawn from a vein in the elbow crease.

The procedure takes only a few minutes, is minimally invasive, and is generally well tolerated. After blood collection, minor bruising, discomfort, or temporary tenderness may occur.

The sample is then processed in the laboratory to determine SHBG concentration.

Sources:

https://labs.selfdecode.com/blog/sex-hormone-binding-globulin/
https://medlineplus.gov/lab-tests/shbg-blood-test/
https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=167&ContentID=shbg_blood
https://www.webmd.com/a-to-z-guides/what-is-sex-hormone-binding-globulin
https://en.wikipedia.org/wiki/Sex_hormone-binding_globulin
https://www.healthline.com/health/low-shbg

IMPORTANT!

It is crucial to remember that the information provided here is not intended for self-diagnosis or self-treatment. If you experience any symptoms or exacerbation of a condition, it is essential to consult a healthcare professional for proper diagnosis and treatment recommendations. Only a qualified specialist can make an accurate diagnosis and prescribe appropriate treatment. For the most accurate and consistent evaluation of test results, it is recommended to have them performed at the same laboratory, as different laboratories may use varying methods and units of measurement for similar tests.