Antibody profile for IBD, IgA/IgG: cANCA, pANCA, ASCA, DNA-bound lactoferrin, pancreatic antigens rPAg1 (CUZD1)/rPAg2 (GP2), intestinal goblet cells
3 days 
Available with home visit Please note that independent interpretation of test results is not appropriate. The information provided below is for informational purposes only.
An extended serological profile that includes the detection of IgA and IgG antibodies associated with inflammatory bowel diseases (IBD), particularly Crohn’s disease and ulcerative colitis.
The profile includes several groups of serological markers that may have different associations with specific forms of IBD. ASCA and CUZD1/GP2 antibodies are more frequently associated with Crohn’s disease, while pANCA/atypical ANCA profiles, DNA-bound lactoferrin antibodies and intestinal goblet cell antibodies are more frequently described in ulcerative colitis.
The test has supplementary diagnostic value and is used in addition to clinical assessment, endoscopic and histological investigations, and other laboratory tests.
Indications
- Suspected inflammatory bowel disease
- Chronic or recurrent diarrhea
- Presence of blood and/or mucus in the stool
- Recurrent or persistent abdominal pain
- Unexplained weight loss
- Intestinal symptoms associated with signs of systemic inflammation
- Anemia, iron deficiency or other signs of unexplained malabsorption
- Suspected Crohn’s disease or ulcerative colitis
- Unclear or contradictory results of previous investigations
- Unclassified inflammatory bowel disease (IBD-U)
- Need for additional differential assessment of Crohn’s disease and ulcerative colitis
Composition
- cANCA IgA/IgG — antibodies against the cytoplasmic ANCA pattern; classic cANCA is more commonly associated with ANCA-associated vasculitis and has additional differential diagnostic value within this profile.
- pANCA IgA/IgG — antibodies against the perinuclear ANCA pattern; an atypical pANCA profile is more frequently found in ulcerative colitis and may be used as an additional serological marker.
- ASCA IgA/IgG — antibodies against Saccharomyces cerevisiae, more frequently detected in Crohn’s disease.
- Anti-rPAg1 (CUZD1)/rPAg2 (GP2) IgA/IgG antibodies — antibodies against antigens associated with the exocrine component of the pancreas; more frequently detected in Crohn’s disease.
- Intestinal goblet cell antibodies IgA/IgG — additional serological markers described predominantly in association with ulcerative colitis.
- DNA-bound lactoferrin antibodies IgA/IgG — additional markers associated with an atypical pANCA profile and more frequently described in ulcerative colitis.
Contraindications
There are no specific contraindications to testing the antibodies included in this profile.
Temporary restrictions on venous blood collection may be related to the patient’s general condition. In case of poor general health, significant dehydration or other special circumstances, prior consultation with a healthcare professional is recommended.
Procedure
The test requires a venous blood sample.
Blood is usually collected from a vein in the elbow area and takes a few minutes. After the procedure, the patient may resume normal activities if their general condition allows.
Limitations
The serological profile has supplementary diagnostic value.
A positive or negative result cannot independently confirm or exclude inflammatory bowel disease. Serological markers should be interpreted together with symptoms, medical history, laboratory findings, endoscopy, histology and other diagnostic methods.
Sources:
https://pubmed.ncbi.nlm.nih.gov/19758145/
https://en.wikipedia.org/wiki/P-ANCA
https://www.ncbi.nlm.nih.gov/books/NBK553208/
https://pubmed.ncbi.nlm.nih.gov/1996606/
IMPORTANT!
It is crucial to remember that the information provided in this section is not intended for self-diagnosis or self-treatment. If experiencing pain or exacerbation of a condition, it is essential to consult a qualified medical professional for proper diagnosis and treatment. Only a qualified specialist can accurately diagnose and determine appropriate treatment. To obtain the most accurate and consistent evaluation of test results, it is recommended to have them performed at the same laboratory. Different laboratories may use varying methods and units of measurement for similar tests.
Preparation:
No special preparation is generally required specifically for the detection of these antibodies.
It is recommended to:
- maintain your usual fluid intake;
- avoid significant dehydration before blood collection;
- follow your regular diet; no special dietary restrictions are required;
- do not discontinue prescribed medications without medical advice;
- inform your physician or laboratory staff about any medications you are taking, including immunosuppressive therapy, as well as any diagnosed medical conditions.
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