Deamidated gliadin peptide (DGP) antibodies, IgG
1 day 
Available with home visit Deamidated Gliadin Peptide (DGP) Antibody, IgG testing is a laboratory test that detects immunoglobulin G (IgG) antibodies directed against deamidated gliadin peptides.
The test is used as part of the comprehensive diagnosis of celiac disease – an autoimmune condition in which gluten consumption triggers an immune response and damage to the lining of the small intestine.
Measurement of DGP IgG antibodies may be particularly informative in certain clinical situations, including the evaluation of patients with IgA deficiency, when standard IgA antibody tests may have limited diagnostic value.
The test result is interpreted together with clinical symptoms, other serological tests and, when necessary, the results of endoscopic and histological examinations.
Indications
- suspected celiac disease;
- presence of symptoms characteristic of celiac disease or other conditions associated with gluten consumption;
- persistent diarrhea, abdominal bloating, pain, or discomfort of unclear origin;
- unexplained weight loss or insufficient weight gain;
- iron-deficiency anemia of unclear origin;
- delayed physical development in children;
- other clinical or laboratory signs that may indicate impaired nutrient absorption;
- suspected celiac disease in patients with total IgA deficiency;
- additional serological evaluation as recommended by a physician.
Limitations
The test result cannot independently confirm or exclude celiac disease. A negative result does not always rule out the disease, particularly if a gluten-free diet has been followed before testing.
For accurate interpretation of the result, the clinical picture and other laboratory findings should be taken into account. In the diagnosis of celiac disease, tissue transglutaminase (tTG) antibodies and total IgA are also usually evaluated; additional investigations may be required in certain cases.
Procedure
Venous blood is collected for the test. The sample is then sent to the laboratory to determine the level of IgG antibodies against deamidated gliadin peptides.
The blood collection procedure takes a few minutes.
Sources:
https://pubmed.ncbi.nlm.nih.gov/36602836/
https://www.worldgastroenterology.org
https://gi.org/page/4/?s=celiac
https://www.nice.org.uk/guidance/ng20
https://onlinelibrary.wiley.com/doi/10.1097
Preparation:
No special preparation is required for the test.
It is preferable to collect the blood sample before starting a gluten-free diet, as excluding gluten from the diet may lead to a decrease in antibody levels and may affect the diagnostic value of the test.
Before blood collection, it is recommended to avoid intense physical activity and emotional stress. Unless otherwise advised by a physician, blood may be collected after the usual meal; if other tests are performed at the same time, the specific preparation requirements for those tests should be followed.
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